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KMID : 0603820130190020168
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Journal of Experimental & Biomedical Science
2013 Volume.19 No. 2 p.168 ~ p.172
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(E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine inhibits Inducible Nitric Oxide Synthase Expression in RAW264.7 Macrophages Stimulated with Lipopolysaccharide
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Gu Gyo-Jeong
Eom Sang-Hoon
Suh Chang-Won
Koh Kwang-Oh
Kim Dae-Young
Youn Hyung-Sun
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Abstract
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Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. TLR4 has been identified as the receptor for lipopolysaccharide (LPS), which is a cell wall component of gram-negative bacteria. The activation of TLR4 signaling by LPS leads to the activation of NF-κB and the expression of pro-inflammatory gene products such as cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). To evaluate the therapeutic potential of (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine (NVPP), previously synthesized in our laboratory, NF-κB activation and iNOS and COX-2 expression induced by LPS were examined. NVPP inhibited the activation of NF-κB induced by LPS. NVPP also suppressed the iNOS expression induced by LPS but it did not suppress COX-2 expression induced by LPS. These results suggest that NVPP has the specific mechanism for anti-inflammatory responses.
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KEYWORD
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Cyclooxygenase-2, Lipopolysaccharide, NF-κB, Inducible nitric oxide synthase, (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine
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